Abstract
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). The risk of developing NAFLD is highly variable among individuals and determined by environmental and genetic factors. GWAS studies identified several genetic risk factors, and genetic risk scores (GRS) were developed for risk stratification. NAFLD susceptibility is significantly associated with four genetic variants: PNPLA3 rs738409 C>G, TM6SF2 rs58542926 C>T, rs641738 C>T close to MBOAT7 locus, GCKR rs1260326 C>T.
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