Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers

Abstract

IgA vasculitis (IgAV) is a leukocytoclastic vasculitis affecting small vessels and is more common in children than in adults. In this study, we aimed to investigate the effects of oxidative stress in adult IgAV patients by Dynamic Thiol Disulfide Homeostasis (DTDH) and Ischemia Modified Albumin (IMA) levels. We also aimed to correlate the presence of inflammation detected by C-Reactive Protein (CRP) and Highly Sensitive C-Reactive Protein (hsCRP) with these oxidative stress parameters. Forty-one IgAV patients and forty-five controls were included in the study. Patients were classified as "active" or "in remission" according to the British Vasculitis Activity Score (BVAS). Measured parameters were compared between the groups. DTDH, IMA, CRP and hsCRP parameters were analyzed in both patient and control groups. According to our results, disulfide (p=0.047), index 1 (p<0.001), index 2 (p<0.001), IMA (p<0.001), CRP (p=0.005) and hsCRP (p=0.004) levels were significantly increased while native thiol (p<0.001), total thiol (p<0.001) and index 3 (p<0.001) levels were significantly decreased in IgAV patients. The results of this study show that oxidative stress is associated with IgAV disease and also with disease severity. The oxidative stress parameters evaluated were also correlated with markers of inflammation.