Evaluation of adaptogenic activity of Neurotip capsules by swimming endurance and chronic stress model

Abstract

Stress is the disturbed homeostatic condition of the organism, and it is represented by non-specific response of the body to any demand imposed on it. Stress brings various changes in physiological condition of the organism, but various mechanism of the body will counteract to maintain homeostasis. Neurotip capsule is effective Ayurvedic treatment for stress related disorders. Neurotip capsules have unique combination of herbs like Jatamansi, Guduchi, Shankapushpi, Ashwagandha, and Probiotics. These herbs are known to sooth the mind, promote calmness and act as a stress buster. In present research study Neurotip formulation was screened for acute toxicity study and sub chronic oral toxicity study on adult albino mice. Animals were observed for behavioural changes, neurological changes and autonomic profile changes. There was no noticeable toxicity and death observed in animals when treated with highest dose of 5000mg/ kg of the formulation. Neurotip was tested on swimming endurance of mice. The results were compared with standard group treated with Geriforte. Test formulation was evaluated by chronic stress model in rats using Omeprazole as standard drug. Assessment of ulcer induction was done to check adaptogenic potential of Neurotip. Ulcer protection by test formulation was found to be 68.44% showing good antistress effects.