Abstract
The Peganum harmala, commonly known as syrian street, belongs to the family Zygophyllaceae. Peganum harmala L is widely used in traditional medicine and pharmacology. The evaluation of toxic properties of Peganum harmala is crucial when considering public health protection because exposure to plant extracts can result in undesirable effects on consumers. Hence, in this study the acute IP toxicity of the total alkaloids of Peganum harmala L seeds was investigated in female rats. The oral dose (60 mg/kg) of tested plant extract was administered to two groups of animals (group I and II) in single dose and third group III is control. The first treated group is sacrificed after 24 hours and the second treated group and control group are sacrificed after 5 days. Throughout the treatment, changes in behavioral pattern, clinical sign and body weight of rats in treatment groups are observed. Also, a significant decrease in relative liver mass and serum biochemical parameters (AST, ALT, PAL, Bil D and Bil T) were observed. An increase in red blood cells, hemoglobin and hematocrit was recorded in group II. Histological examination shows that the seed extract of Peganum harmala L has no remarkable toxic effect on the liver of the treated animals of the second group. The result indicates that the IP administration of the total alkaloids of Peganum harmala L seeds plant did not produce any significant toxic effect in albino rats.
Highlights
Medicinal plants are becoming more widely used, especially among people in the Third World, because of the high cost of drugs, and because of the despair of drugs that sometimes do not give the desired therapeutic results.The misuse of medicinal plants by patients with mostly chronic diseases leads to medical complications
It is locally known as Harmel, whose active ingredients are alkaloids whose chemical structure associates an indole nucleus with a pyridine nucleus: harmane, harmine, harmaline, harmalol [3]
To be able to follow the animals and identify them, they were marked on their body by a solution of Evaluation of Acute Toxicity of the Alkaloids of Peganum harmala L Seeds in Albino Wistar Female Rats picric acid (2%) All experimental procedures were conducted in accordance with the guide for care and use of laboratory animals and in accordance with the scientific council of the Faculty of Natural Sciences and Life of the University Ferhat Abbes Sétif 1
Summary
Medicinal plants are becoming more widely used, especially among people in the Third World, because of the high cost of drugs, and because of the despair of drugs that sometimes do not give the desired therapeutic results. Plants are the cause of much intoxication, especially in rural areas [1] Among these plants, Peganum harmala grows in semi-arid rangeland [2]. Peganum harmala grows in semi-arid rangeland [2] It is locally known as Harmel, whose active ingredients are alkaloids whose chemical structure associates an indole nucleus with a pyridine nucleus: harmane, harmine, harmaline, harmalol [3]. The Péganum harmala, commonly known as syrian street and wild street, is a flowering plant and is widely distributed in central Asia, North Africa and the Middle East. It has been introduced in America and Australia [2]. We tried to study the effect of the alkaloids of seeds of Peganum harmala on the liver and the blood of female rats (Albinos-Wistar) under conditions of acute toxicity
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