Abstract
In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity.
Highlights
It is well known that many medicinal plants are beneficial sources of minerals, vitamins, dietary fiber and various phytochemicals [1]
Acute skin irritation and phototoxicity tests were performed using animal models to analyze the in vivo effects of the LEE: EVALUATION OF SKIN IRRITATION AND PHOTOTOXICITY BY Angelica keiskei EXTRACTS
The slice‐dried leaves were pulverized with a homogenizer (20,000 rpm for 15 min; Shin‐Il, Seoul, Korea) to obtain aqueous and ethanol fractions of Angelica keiskei leaves and powder
Summary
It is well known that many medicinal plants are beneficial sources of minerals, vitamins, dietary fiber and various phytochemicals [1]. The highly potent antioxidant properties of the fresh leaves make these functional food ingredients Members of this group of plants have traditionally been used as anti‐inflammatory agents, as well as remedies for colds, flu, hepatitis, arthritis, indigestion, coughing, chronic bronchitis, fever, cancer and bacterial infections [5,6,7] due to the group's flavonoid, saponin and coumarin content. Since various side-effects may be caused by acute or chronic toxicity, irritation or sensitization, various in vivo animal models, as well as in vitro, semi in vivo and ex vivo models, should be used in further toxicity studies, they are modified tests [16]. Acute skin irritation and phototoxicity tests were performed using animal models to analyze the in vivo effects of the LEE: EVALUATION OF SKIN IRRITATION AND PHOTOTOXICITY BY Angelica keiskei EXTRACTS. Various parameters were measured by comparing the acute toxicity tests with calculated degrees to ascertain whether the Angelica extracts may potentially be used for cosmetic applications without damaging the skin
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