Abstract
The research evaluated the acute and subchronic toxicities of An Nguyet Khang tablets in experimental animals. Acute toxicity was defined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD's recommendation in Wistar rats with oral doses of 0.65 g/kg/day (equal to recommended human dose) and 1.95 g/kg/day (3 times as high as recommended human dose) in fourconsecutive weeks. We found that An Nguyet Khang tablet at the highest dose used for mice (35.15 g/kg) did not express acute toxicity in mice. Regarding the subchronic toxicity test, after oral administration of An Nguyet Khang tablets, hematological parameters, hepato-renal functions, and microscopic images of the liver and kidney were unchanged compared with the control group. In conclusion, An Nguyet Khang tablets did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.
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