Abstract
The therapeutic activity of drugs is related to the concentration of free unbound drug in plasma [l, 21 which is dependent on, among other factors, the ionization and solubility of the drug. In addition, a knowledge of the acidity constants of compounds of pharmaceutical interest is required for the solution of many drug-related problems [3]. However, the choice of method for determining the ionization constants of drugs is severely restricted in a number of cases by poor solubility which does not allow application of normal potentiometric and conductimetric techniques for the determination of the constants in water. In such cases, solubility measurements in combination with any appropriate quantitative analytical technique [4-E] may be used. Although hydroalcoholid solutions may be employed to increase the solubility, studies intended to be of clinical relevance should be conducted in aqueous buffers at physiological temperature and ionic strength. In this report, an equation is proposed that allows the overlapping acidity constants of amphoteric substances to be calculated from solubility measurements.
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