Abstract
BackgroundSo-Cheong-Ryong-Tang, a traditional Korean medicine, has been used empirically for the treatment of asthma, allergic rhinitis, and colds for hundreds of years. However, its genotoxicity has been rarely examined.MethodsWe therefore investigated the genotoxicity of an aqueous extract of So-Cheong-Ryong-Tang (SCRT) in two in vitro and one in vivo assays: a bacterial reverse mutation assay (Ames test), a chromosomal aberration assay, and a micronucleus assay, respectively.ResultsIn the bacterial reverse mutation assay, SCRT did not increase revertant colony numbers in Salmonella. typhimurium strains (TA98, TA100, TA1535, and TA1537) or an Escherichia coli strain (WP2 uvrA) regardless of metabolic activation or the duration of treatment. However, statistically significant differences in the incidence of chromosomal aberrations following SCRT >4000 μg/mL were observed in Chinese hamster lung cells exposed with or without an S9 enzyme and cofactor mixture.ConclusionsThese results suggest further genotoxic testing of SCRT, such as a comet assay, to ascertain its generally recognized safety.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0737-x) contains supplementary material, which is available to authorized users.
Highlights
-Cheong-Ryong-Tang, a traditional Korean medicine, has been used empirically for the treatment of asthma, allergic rhinitis, and colds for hundreds of years
Lee et al BMC Complementary and Alternative Medicine (2015) 15:235 acute toxicity. We assessed these properties using the standard battery of tests recommended by the Korea Food and Drug Administration (KFDA): the bacterial reverse mutation test (Ames test), the chromosome aberration test, and the in vivo micronucleus test
The analysis was conducted at a flow rate of 1.0 mL/min with photodiode array (PDA) detection at 230 nm, 254 nm, and 280 nm
Summary
-Cheong-Ryong-Tang, a traditional Korean medicine, has been used empirically for the treatment of asthma, allergic rhinitis, and colds for hundreds of years. The traditional herbal medicine So-Cheong-Ryong-Tang (known as Xiao-Qing-Long-Tang in traditional Chinese medicine and as Sho-seiryu-to in Japanese Kampo medicine) is a mixture of eight herbal preparations (Herba Ephedrae, Radix Paeoniae, Fructus Schisandrae, Tuber Pinelliae, Asiasari Radix, Rhizoma Crudus Zingiberis, Ramulus Cinnamomi, and Radix et Rhizoma Glycyrrhizae). This mixture has long been used to treat allergic rhinitis, bronchitis, and bronchial asthma [1]. Lee et al BMC Complementary and Alternative Medicine (2015) 15:235 acute toxicity.
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