Abstract

The Merck KGaA Chromolith RP-18 column is based on a unique sorbent material consisting of a monolithic rod which has a high internal area and porosity, allowing quality separations in a minimum of time. The use of such a silica-based monolithic column has been applied to one of our most challenging HPLC separations, that is the impurity profiling of an analog of Taxol®. Different types of conventional HPLC columns with silica particle-based packings, as well as the Chromolith RP-18 column, have been investigated with a combination of mobile phases to achieve the separation of all the impurities of a synthetic taxane currently under development. The performance of the Merck KGaA Chromolith column was found to compare quite favorably to a conventional silica particle-based column.

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