Evaluation of a Preventive Effect of a Lotion on the Formation of Stretch Marks. Quantification of Contractile Forces Developed by Fibroblasts from Early Stretch Marks (Red Color) and from Healthy Surrounding Skin Using GlasBox&amp;lt;sup&amp;gt;Plus&amp;lt;/sup&amp;gt; Device

Carol Courderot-Masuyer,Philippe Humbert,Ferial Fanian,Sophie Robin

doi:10.4236/jcdsa.2017.72016

Abstract

Stretch marks are cutaneous lesions occurring frequently in weight gain during puberty and early adult life. Previous studies showed that highest contractile forces were developed by fibroblasts from early stretch marks (SMF) compared to those developed by fibroblasts from normal healthy skin (HF) of the same patient. The aim of the present study was to evaluate a possible preventive effect of a topical preparation (containing vitamins C and E and botanical extracts including natural extract of Calendula, Aloe Vera and Evening Primrose Oil) on the formation of stretch marks using GlasboxPlus® device. In the presence of the tested mixture, a significant overall decrease in contractile forces of SMF was noted for 24 hours of measurements compared to control SMF and made it possible to restore their capacity to the same level as HF indicating a possible preventive effect of the tested mixture. The synergistic effects of these components are certainly responsible for the decrease in contractile forces of early stretch marks fibroblasts.

Highlights

IntroductionViennet et al have shown that fibroblasts from early stretch marks were the richest cells in alpha-smooth muscle actin filaments and generated the highest contractile forces compared to than normal fibroblasts using the device GlasBox [4]
Previous studies showed that highest contractile forces were developed by fibroblasts from early stretch marks (SMF) compared to those developed by fibroblasts from normal healthy skin (HF) of the same patient
In the presence of the tested mixture, a significant overall decrease in contractile forces of stretch marks fibroblasts (SMF) was noted for 24 hours of measurements compared to control SMF and made it possible to restore their capacity to the same level as healthy fibroblasts (HF) indicating a possible preventive effect of the tested mixture

Summary

Introduction

Viennet et al have shown that fibroblasts from early stretch marks were the richest cells in alpha-smooth muscle actin filaments and generated the highest contractile forces compared to than normal fibroblasts using the device GlasBox [4]. The purpose of this study was to evaluate the relaxing effect of a lotion containing vitamins C and E and botanical extracts on fibroblasts obtained from early stretch marks in comparison with normal fibroblasts from neighboring skin of the same patient. The tested lotion is a mixture of components with anti-inflammatory properties such as panthenol [5], shea butter [6], niacinamide [7], calendula [8]. Some of them have moisturing properties such as panthenol, avocado oil, cocoa seed butter and aloe vera [9] and vitamin E. The mixture provides components with antioxidant properties such as vitamin E and vitamin C and two oils, avocado oil rich source of vitamin E and sweet orange oil, rich source of naturally vitamin C

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Conclusion