Evaluation of a Premixed Insulin Analog Suspension in Japanese People with Type 2 Diabetes and the Clinical Importance of Improved Injection Techniques: A Cross-Sectional Pilot Study.

Kunihiro Suzuki,Kanako Kato,Kazunori Yanagi,Hisamoto Kuroda,Masanori Shimizu,Chie Aoki,Yoshimasa Aso,Shintaro Sakurai

doi:10.1007/s13300-017-0228-9

Kunihiro Suzuki, Kanako Kato + Show 6 more

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https://doi.org/10.1007/s13300-017-0228-9

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Journal: Diabetes Therapy	Publication Date: Jan 24, 2017
Citations: 1	License type: CC BY 4.0

Affiliation: Dokkyo Medical University

Abstract

IntroductionPatients with type 2 diabetes, who live in Asian countries, often use premixed insulin analogs. However, if these solutions are insufficiently mixed prior to use, patients will receive inaccurate doses of intermediate- and/or short-acting insulin, which could affect diabetes control. This study aimed to determine whether insulin users were correctly resuspending premixed insulin analog solutions prior to use.MethodsWe investigated whether Japanese patients with type 2 diabetes were correctly resuspending their premixed insulin analog solutions by assessing the optical densities (ODs) of the solutions.ResultsAmong 476 patients who used premixed insulin analogs, we found that the ODs of residual insulin differed significantly from the control values, particularly for high-mix insulin suspensions.ConclusionOur findings suggest that patients should be educated about the importance of properly resuspending these insulin analog solutions prior to use.Trial RegistrationUniversity Hospital Medical Information Network (UMIN No. 000022329).

Highlights

Patients with type 2 diabetes, who live in Asian countries, often use premixed insulin analogs
Premixed insulin analogs, such as biphasic insulin aspart 30, 50, and 70 (NovoRapid 30, 50, and 70; Novo Nordisk A/S, Søborg, Denmark) and lispro mix 25 and 50 (Eli Lilly and Company, Indianapolis, IN, USA), are forms of insulin therapy commonly used by patients with type 2 diabetes in Asian countries [1, 2]
We investigated whether insulin users were correctly resuspending their premixed insulin analogs by measuring the optical densities (ODs) of the insulin solutions, which has been reported as the simplest method for assessing cloudiness [5]

Summary

Introduction

Patients with type 2 diabetes, who live in Asian countries, often use premixed insulin analogs If these solutions are insufficiently mixed prior to use, patients will receive inaccurate doses of intermediate- and/or short-acting insulin, which could affect diabetes control. Methods: We investigated whether Japanese patients with type 2 diabetes were correctly resuspending their premixed insulin analog solutions by assessing the optical densities (ODs) of the solutions. Enhanced content To view enhanced content for this article go to http://www.medengine.com/Redeem/ 0387F06039B2EA5A Premixed insulin analogs, such as biphasic insulin aspart 30, 50, and 70 (NovoRapid 30, 50, and 70; Novo Nordisk A/S, Søborg, Denmark) and lispro mix 25 and 50 (Eli Lilly and Company, Indianapolis, IN, USA), are forms of insulin therapy commonly used by patients with type 2 diabetes in Asian countries [1, 2]. We investigated whether insulin users were correctly resuspending their premixed insulin analogs by measuring the optical densities (ODs) of the insulin solutions, which has been reported as the simplest method for assessing cloudiness [5]

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