Abstract
BackgroundAnemia is a widespread public health problem associated with an increased risk of morbidity and mortality, especially in pregnant women. This study examined the agreement between a portable hemoglobin photometer and a laboratory analyzer in determining hemoglobin level in pregnant women.MethodsThis study recruited 69 pregnant women in Tibet, China. Capillary blood samples were taken to measure hemoglobin concentration using the hemoglobin photometer and the laboratory analyzer. Limit of agreement, concordance and intraclass correlation coefficient were used to evaluate the agreement. Laboratory measurement was considered as the standard reference method. Sensitivity and specificity were calculated to assess the error in screening for anemia.ResultsMean difference between the two methods was -2.1 g/l. wide 95% limits of agreement were found (-22.6 g/l to 18.4 g/l). The intraclass correlation coefficient was 0.795, and concordance correlation coefficient was 0.793. Sensitivity and specificity were 94.9% and 76.7% respectively. Positive predictive value was 84.1%, and negative predictive value was 92.0%.ConclusionThis hemoglobin photometer is not recommended for determining hemoglobin concentration in pregnancy in a high altitude area.
Highlights
IntroductionThis study examined the agreement between a portable hemoglobin photometer and a laboratory analyzer in determining hemoglobin level in pregnant women
Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality, especially in pregnant women
HCHB1, the haemoglobin concentration measured by HemoCue®; LAHB2, the haemoglobin concentration measured by laboratory analyzer; SD, standard deviation
Summary
This study examined the agreement between a portable hemoglobin photometer and a laboratory analyzer in determining hemoglobin level in pregnant women. Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality, especially in pregnant women [1]. Anemia during pregnancy is a well-established risk factor for both the mother and the fetus [3]. Hemoglobin assessments are relatively precise and are used to screen individuals for anemia, to assess the iron status of populations, and to evaluate responses to nutritional interventions. The portable hemoglobin meter (HemoCue) has been widely used in recent years [4].
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