Abstract
Several aspects of platelet serotonergic function have been investigated in patients with major depression. The specificity of the decreased number of platelet binding sites for [3H]-imipramine were investigated. Blood samples for platelet receptor binding were obtained from normal controls (n-102), patients with panic disorder (n-18), atypical depression (n-7), mania (n-16), fibromyalgia (n-24), and Alzheimer's disease (n-14) as well as patients with major depression (n-155). Only patients with major depression exhibited a significant decrease in the density of [3H]-imipramine binding sites on platelets. In addition, in vitro experiments revealed that imipramine was less effective in inhibiting radiolabeled serotonin (5HT) uptake into platelets in elderly depressed patients, when compared to either elderly normal controls or young-middle aged depressed patients. Lastly, an increase in the concentration of plasma α1-acid glycoprotein, a putative endogenous inhibitor of the [3H]-imipramine binding site, in drug-free depressed patients was observed.
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