Abstract
At present, (14)C-urea breath test is considered a gold standard for diagnosis of Helicobacter pylori infection, but they are time-consuming, comparably expensive, and usually not portable tests. The aim of our study was to establish the diagnostic value of the novel, inexpensive, quick, and convenient to use (14)C-urea breath test "Heliprobe", Noster AB, Sweden. Helicobacter pylori testing using "Heliprobe" was performed in 108 consecutive patients. Helicobacter pylori was also investigated using rapid urease test and Giemsa stained histological specimens according to Sydney system. The diagnostic values of "Heliprobe" assuming the Helicobacter pylori positivity, if the results of two tests (rapid urease test and histology) are positive, were: sensitivity--97%, specificity--87%, positive predictive value--93%, negative predictive value--95%, accuracy--94%. The diagnostic values of "Heliprobe" assuming the Helicobacter pylori positivity, if at least the results of one test are positive: sensitivity--92%, specificity--100%, positive predictive value--100%, negative predictive value--84%, accuracy--94%. CONCLUSIONS. The novel, quick, convenient to use (14)C-urea breath test "Heliprobe" is accurate, reliable, and useful for the diagnosis of Helicobacter pylori infection in routine clinical practice.
Highlights
Since the discovery of Helicobacter pylori (HP) infection [1], a huge amount of research has been carried out to define the role of this microorganism in the gastroduodenal pathology [2]
HP testing was performed in 108 consecutive patients who had not been using proton pump inhibitors, bismuth compounds, antibiotics, and nonsteroidal antiinflammatory drugs for at least one month before testing
The evaluations of sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the test are presented in Table
Summary
Since the discovery of Helicobacter pylori (HP) infection [1], a huge amount of research has been carried out to define the role of this microorganism in the gastroduodenal pathology [2]. 13C-UBT is not invasive, highly accurate, but time consuming, comparably expensive, and usually not portable [6] These inconveniences could be somehow accepted in the economically developed Western Europe and North America countries. In the developing African, Asian, Eastern European, and other countries, where prevalence of HP is high, there is an urgent need for accurate, inexpensive, and rapid urea breath tests [7]. In these countries, up until recently, the most cheap and accepted diagnostic tool remains rapid urease test (RUT), which is invasive and related to the complications of endoscopy
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