Abstract
The management of acute and chronic wounds is still a socioeconomic burden for society due to the lack of suitable tools capable of supporting all the healing phases. The exponential spread of diabetes worldwide and the consequent increase of complicated diabetic ulcers require further efforts to develop scalable, low-cost, and easy-to-use treatments for tackling this emergency. Recently, we explored the fabrication of a polyvinylpyrrolidone/hyaluronic acid-based bilayer wound dressing, characterizing its physicochemical features and detailing its excellent antimicrobial activity. Here, we further demonstrate its biocompatibility on fibroblasts, keratinocytes, and red blood cells. The bilayer shows anti-inflammatory properties, statistically reducing the level of IL-6, IL-1β, and TNF-α, and a capacity to accelerate wound healing in vitro and in healthy and diabetic mice models compared to untreated mice. The outcomes suggest that this bilayer material can be an effective tool for managing different skin injuries.
Highlights
Received: 27 January 2022Wound repair is considered one of the most complex biological procedures of our body, and it is divided into four main phases: hemostasis, inflammation, proliferation, and remodelling [1]
An altered ability to modulate the release of cytokines, important mediators that perform multiple functions in the inflammatory phase, and a high level of matrix metallo-proteinases lead to an arrest at the very early stages of the wound repair process [10]
In a recent study [41], we presented the fabrication of a PVP-based multifunctional bilayer material using two water-based scalable approaches
Summary
Wound repair is considered one of the most complex biological procedures of our body, and it is divided into four main phases: hemostasis, inflammation, proliferation, and remodelling [1]. In normal healing, these phases occur in a sequential but overlapped way, and they are completed in a period between three weeks and some months, leading to the formation of scar tissue [2,3]. Various complications can occur and affect the damage recovery time required Bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus can readily colonize wounds, causing aggressive and intricate infections [4,5]. Diabetic vascular trouble could reduce oxygen transport to the Accepted: 17 February 2022
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