Abstract

Introduction. The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock. Methods. This study used cardiovascular measurements recorded during a porcine trial studying the efficacy of large-pore hemofiltration for treating septic shock. Four Pietrain pigs were instrumented and induced with septic shock. A subset of the measured data, representing clinically available measurements, was used to identify subject-specific cardiovascular models. These models were then validated against the remaining measurements. Results. The system accurately matched independent measures of left and right ventricle end diastolic volumes and maximum left and right ventricular pressures to percentage errors less than 20% (except for the 95th percentile error in maximum right ventricular pressure) and all R 2 > 0.76. An average decrease of 42% in systemic resistance, a main cardiovascular consequence of septic shock, was observed 120 minutes after the infusion of the endotoxin, consistent with experimentally measured trends. Moreover, modelled temporal trends in right ventricular end systolic elastance and afterload tracked changes in corresponding experimentally derived metrics. Conclusions. These results demonstrate that this model-based method can monitor disease-dependent changes in preload, afterload, and contractility in porcine study of septic shock.

Highlights

  • The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock

  • The limited measurement set typically available in the intensive care unit (ICU) is sometimes insufficient to give a full picture of cardiovascular status

  • Temporal variance was analysed over T0–T60 and T30–T60 because sometimes the symptoms of septic shock do not manifest immediately after the endotoxin infusion at T30

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Summary

Introduction

The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock. These results demonstrate that this model-based method can monitor disease-dependent changes in preload, afterload, and contractility in porcine study of septic shock. Other model-based methods have been used to estimate surrogate markers of cardiovascular performance from clinically available data These approaches have only been used to identify a small number of hemodynamic parameters [6] or only describe localised behaviour [7, 8], normally to obtain estimates of CO [9,10,11,12,13,14,15,16]. A broader approach that describes the effects of disease on parameters of cardiac function, as well as parameters of systemic and pulmonary flows, is required

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