Abstract
A direct rapid immunohistochemical test (dRIT) was evaluated under field and laboratory conditions to detect rabies virus antigen in frozen and glycerol-preserved field brain samples from northwestern Tanzania. Compared to the direct fluorescent antibody test, the traditional standard in rabies diagnosis, the dRIT was 100% sensitive and specific.
Highlights
All material published in Emerging Infectious Diseases is in the public domain and may be used and reprinted without special permission; proper citation, is required
A rapid immunohistochemical test (RIT) to detect rabies virus (RABV) antigen has been developed in the Rabies Section of the Centers for Disease Control and Prevention (CDC) by incorporating various components of existing immunoperoxidase techniques [6]
We report findings of a preliminary study to evaluate the direct rapid immunohistochemical test (dRIT), comparing results of the dRIT carried out under field conditions in Tanzania with the dRIT and direct fluorescent-antibody assay (DFA) performed at CDC
Summary
All material published in Emerging Infectious Diseases is in the public domain and may be used and reprinted without special permission; proper citation, is required. A direct rapid immunohistochemical test (dRIT) was evaluated under field and laboratory conditions to detect rabies virus antigen in frozen and glycerol-preserved field brain samples from northwestern Tanzania. A rapid immunohistochemical test (RIT) to detect rabies virus (RABV) antigen has been developed in the Rabies Section of the Centers for Disease Control and Prevention (CDC) by incorporating various components of existing immunoperoxidase techniques [6].
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