Evaluation of a CT to Cone-Beam CT Deformable Registration Algorithm

Abstract

The advent of on-board cone-beam CT (CBCT) imagers for radiation therapy delivery devices offers the potential for daily dosimetry and adaptive therapy. Heretofore this potential has been limited by several artifacts in the CBCT volumes. This obstacle may require surrogates with reliable density values to be used for recalculation of dosimetry, such as a CT volume deformed to the treatment space of the CBCT. Additionally, automatically accumulating dose to critical structures and target volumes requires structures defined on the original planning CT to be deformed into the treatment space identified by the CBCT.