Abstract

A combined immunoassay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II (Bioelisa, Launch Diagnostics) has been evaluated to determine its suitability for routine use in blood donor screening. 84,222 donations were tested from 76,452 donors. One HIV- and 1 HTLV-I-positive donor were identified. The specificity was 99.7%, and the sensitivity for anti-HIV-1, anti- HIV-2, and anti-HTLV-I on 173 positive sera was 100%; 2 of 25 anti-HTLV-IIpositive sera were non-reactive. Although the specificity of the assay is not as high as that of HIV-1/2 kits currently in UK transfusion use, the information gained about donor HTLV antibody status makes the test an attractive alternative to them.

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