Evaluation of a biochemical process to minimize snoring with ambroxol & bromhexine in comparison with their performance in non OSA Bangladeshi patients

Abstract

Snoring is an important sign of sleep-related breathing disorders (SRBD), of the upper airway resistance syndrome (UARS), and of the obstructive sleep apnea (OSA). Snoring is a symptom of nasal obstruction and is associated with cardiovascular diseases. Roommates or bed partners are also suffered by snorers. In-house monitoring of snoring is very useful for evaluation by bed partner or roommate as well as polysomnography in sleeping centre. Process to evaluate and monitoring snoring available in the country are mechanical process. Our objective is to evaluate a biochemical process to minimize snoring with two mucolytic expectorants Ambroxol & Bromhexine and compare their performance in non OSA Bangladeshi patients.32 snorers with no other respiratory disease like asthma , bronchitis etc. and who has ESS score 8-16 and SSS score 2-4,were taken from a Sleep Medicine Centre of Japan Bangladesh Friendship Hospital, 15 students from Bangabandhu Sheikh Mujibur Rahman Hall, Jahangirnagar University and another 15 from University of Development Alternative(UODA). The procedure and scoring were performed by help of roommates and bed partners. Snoring was measured on the basis of Frequency, Loudness, Snoring Index and day time sleepiness using Epworth Sleepiness Scale (ESS). A portable respiratory recording device (PRRD )was used to determine loudness, index and frequency of patient at home and snoring data was also collected from sleep medicine centre where polysomnogram was used. snoring severity objectively were also measured by using Snoring Severity Scale (SSS). excellent snoring suppressing effect was observed in both groups after treating separately with Ambroxol and Bromhexine 30 mg per night. Snoring Frequency, Loudness, Severity, Index and ESS score was reduced markedly in compared to placebo group.