Abstract
[67Ga]labeled 2-acetylpyridine 4,4-dimethylthiosemicarbazone ([67Ga]- [APTSM2]2+) was prepared using freshly prepared [67Ga]GaCl3 and 2-acetylpyridine 4,4-dimethylthiosemicarbazone (APTSM2) for 30 min at 90°C (radiochemical purity: >97% ITLC, >98% HPLC, specific activity: 15–20 Ci/mmol). Stability of the complex was checked in human serum for 37°C. The biodistribution of the labeled compound in vital organs of normal and fibrosarcoma bearing mice were compared with that of free Ga3+ cation up to 24h. Initial SPECT images and biodistribution results showed significant tumor uptake in fibrosarcoma-bearing mice after 2 hour post injection.
Highlights
The interesting physical properties and availability of gallium-67 make it an interesting nuclide for radiopharmaceutical research [1]
The crystal structure of the gallium(III) complex has already been determined by X-ray diffraction as well as other spectroscopic methods [2]
The cytotoxicity assay in several human cancer cell lines (SW480, SK-BR-3 and 41M) suggested that the gallium(III) complex might be endowed with promising antitumour properties [2]
Summary
The interesting physical properties and availability of gallium-67 make it an interesting nuclide for radiopharmaceutical research [1]. Biodistribution of [67Ga]GaCl3 (1.85 MBq, 50μCi) in normal mice 0.5–24h after iv injection via tail vein (ID/g%: percentage of injected dose per gram of tissue calculated based on the area under curve of 184 keV peak in gamma spectrum) (n=5)
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