Abstract
This study investigates the use of [ 99mTc] liposomes for the detection of sentinel lymph nodes. A variety of [ 99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [ 99mTc] regular-sulfur colloid (SC), [ 99mTc] 0.22 μ-filtered-SC, [ 99mTc] reduced heating time 0.22 μ-filtered-SC, and [ 99mTc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [ 99mTc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [ 99mTc] filtered SC preparations > [ 99mTc] regular SC > [ 99mTc] liposomes > [ 99mTc] HSA. [ 99mTc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.
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