Evaluation of 9-Methylamino-Methylanthracene as a Chemical Label for Total Reactive Isocyanate Group: Application to Isocyanate Oligomers, Polyurethane Precursors, and Phosgene

Abstract

Abstract 9-Methylamino-methylanthracene (MAMA) is a secondary amine compound which can be used for derivatization and quantitation of isocyanate compounds by HPLC with detection by fluorescence and ultra-violet light absorbance The compound has potential as a chemical label for determination of airborne total reactive isocyanate group (TRIG) compounds arising from partially polymerized polyurethanes and thermal decomposition products of fully cured polyurethanes Six isocyanate oligomers and polyurethane precursors based on methylene-bis-(phenylisocyanate) (MDI), 1,6-hexamethylene-diisocyanate (HDI), and 2,4- and 2,6-toluenediiosocyanate (TDI) were assayed for isocyanate content using MAMA reagent After reaction of isocyanate with MAMA, the urea derivatives were analyzed by reversed phase HPLC using three detection / quantitation modes: fluorescence with excitation at 245 nm and emission at 414 nm, UV absorbance at 245 nm and UV absorbance at 370 nm. The ratio of absorbance at 245 nm and at 370 nm identifi...