Evaluation of 8-Hydroxy deoxyguanosine levels, as a marker of oxidative stress in chronic gingivitis and chronic periodontitis individuals during the course of phase 1 periodontal therapy in comparison with periodontally healthy individuals

Abstract

Aim: The aim was to evaluate the levels of 8-Hydroxy deoxyguanosine levels, as a marker of oxidative stress in Chronic Gingivitis and Chronic Periodontitis individuals during the course of Phase 1 periodontal therapy in comparison with Periodontally healthy Individuals. Materials and Method: All the individuals were divided into 3 groups each including 16 subjects. Group 1 included healthy subjects and group 3 and 4 included subjects with chronic gingivitis and chronic periodontitis respectively. Saliva samples were collected and the 8-OHdG levels were assessed. Results: The levels reduced to 1.59±0.50 in chronic periodontitis group one month after scaling and root planing. A statistically non-significant value of 0.09 was recorded. The levels in chronic gingivitis group were 1.20±0.89. Conclusion: From the above study it can be concluded that 8-OHdG is an important biomarker of oxidative stress and is increased in patients with chronic gingivitis and chronic periodontitis.