Evaluation effect of different concentration of povidone Iodine on skin wound healing in rabbits

Abstract

The goal of the current study was to assess the effects of povidone iodine 10% in comparison with 5% of povidone iodine on full-thickness cutaneous wounds healing in rabbits. This was on twenty-four healthy male rabbits, weighing from (1.5–1.8 kg). Under the effect of intramuscular administration of a mixture of xylazine hydrochloride 5mg / kg, ketamine hydrochloride 35mg / kg and diazepam 1 mg / kg. On each animal, in the dorsal back area, one square (2 × 2) cm full-thickness skin wounds were made. The animals were divided into two groups, group (A) as the treatment group was treated with 10% povidone iodine daily for 1 time for day 7 post operation. While, at the same time in group (B), the rabbits were treated with 5% povidone iodine. For clinical evaluation, each group was divided into four subgroups (two wounds/subgroup) on 3rd, 5th, 7th, 9th, 14th and 21th days post-wound induction and treatment. Clinically, the result showed that 10 % of iodine was more effective than 5 % of iodine, and the wound healing rate in group (A) was faster than group (B). This was followed by statistical analysis results showing the wound healing process ((20%, 40%), (70%, 85%) contraction) and ((10%, 20%), (50%, 70%) re-epithelization). Respectively, there were significantly more (P≤0.05) than the iodine 5% during the study period. Conclusion; Povidone-iodine solution 10% is more efficient than iodine 5% so that lead to acceleration and enhancement of full-thickness cutaneous wounds healing.