Abstract
Myricitrin was isolated from Cercis chinensis leaves and its antithrombotic activity was evaluated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro and rat acute blood stasis model in vivo. APTT, PT and TT were significantly prolonged and plasma FIB was significantly shortened in myricitrin group compared with model group in vitro. In rat acute blood stasis model, myricitrin (5 mg/mL and 2.5 mg/mL) could extend APTT, PT and TT, increase the level of 6-keto prostaglandin F1α (6-keto-PGF1α) and nitric oxide synthase (eNOS), decrease the level of plasma FIB, thromboxane B2 (TXB2), endothelin-1 (ET-1), blood sedimentation (ESR), hematocrit (PCV), whole blood viscosity (WBV) and plasma viscosity (PV). All of above revealed that myricitrin had good antithrombotic effects.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
