Abstract
Rationale: Recently, albumin-globulin-ratio (AGR), a serological indicator that reflects nutritional status and systemic inflammatory, has been reported to be associated with the prognosis of various cancers (1,2). However, there is currently no research report on its relationship with cancer cachexia. This study aimed to explore the prognostic value of AGR in patients with cancer cachexia through a multi-center retrospective analysis.
Highlights
According to the World Health Organization [1], cancer is the second leading cause of death globally and is responsible for about 10 million deaths per year
We compared the albumin–globulin ratio (AGR) level of patients with and without cachexia among different cancer types, and the results showed that the AGR levels were generally low in patients with cachexia, especially in gastrointestinal cancers (Supplementary Figure 1A)
We explored the distribution of AGR in patients with cancer cachexia through the restricted cubic spine function
Summary
According to the World Health Organization [1], cancer is the second leading cause of death globally and is responsible for about 10 million deaths per year. About one in six deaths is due to cancer. There were an estimated 19.3 million new cancer cases and nearly 10 million cancer deaths worldwide [2]. In China, cancer is still one of the major killers affecting national health. There are about 3.929 million new cancer cases and 2.338 million cancer deaths every year, and the number is still growing [3]. Albumin–globulin ratio (AGR), a serological indicator that reflects nutritional status and systemic inflammatory, has been reported to be associated with the prognosis of various cancers. There is currently no research report on its relationship with cancer cachexia
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