Abstract
Neurogenic bladder (NB) or neurogenic lower urinary tract dysfunction (NLUTD), a dysfunction of the urinary bladder and urethra due to disease of the central nervous system or peripheral nerves, is a major global medical and social problem. Numerous nervous system abnormalities, such as: stroke, Alzheimer’s and Parkinson’s diseases, traumatic spinal cord injury, spinal cord tumors, congenital spina bifida, and diabetes, can cause NB/NLUTD. There are two major types of bladder control problems associated with NB/NLUTD: the bladder becomes either overactive or underactive depending on the nature, level, and extent of nerve damage. This review specifically focuses on the diagnosis and management of NB/NLUTD in China as well as on recent efforts to treat this disease.
Highlights
Neurogenic bladder (NB) or neurogenic lower urinary tract dysfunction (NLUTD), a dysfunction of the urinary bladder and urethra due to diseases of the central nervous system or peripheral nerves, is a major medical and social problem
The loss of supra-spinal control leads to neurogenic detrusor over-activity (NDO), causing urinary incontinence, and detrusor sphincter dyssynergia (DSD), which results in elevated bladder pressure during the storage and voiding phases
Several positron emission tomography (PET) and functional Magnetic Resonance Imaging (MRI) studies have identified brain structures that are activated during bladder filling and voiding in healthy subjects and symptomatic patients [2,3,4]
Summary
Neurogenic bladder (NB) or neurogenic lower urinary tract dysfunction (NLUTD), a dysfunction of the urinary bladder and urethra due to diseases of the central nervous system or peripheral nerves, is a major medical and social problem. NB or NLUTD may be caused by various diseases and events affecting the nervous system controlling the lower urinary tract (LUT), including the bladder and. The loss of supra-spinal control leads to neurogenic detrusor over-activity (NDO), causing urinary incontinence, and detrusor sphincter dyssynergia (DSD), which results in elevated bladder pressure during the storage and voiding phases. NDO, DSD, and high pressure often lead to structural bladder damage, vesicoureteral reflux (VUR), upper urinary tract dilation (UUTD), and renal insufficiency. I review some new work and findings regarding NB and NLUTD in China
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
