Abstract
The disinfection of surfaces in medical facilities is an important element of infection control, including the control of viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Preparations used for surface disinfection are typically characterized via their activity against test organisms (i.e., viruses, bacteria and fungi) in the laboratory. Typically, these methods use a suspension of the test organism to assess the bactericidal, fungicidal or virucidal activity of a given preparation. However, such suspension methods do not fully imitate real-life conditions. To address this issue, carrier methods have been developed, in which microorganisms are applied to the surface of a carrier (e.g., stainless steel, glass and polyvinyl chloride (PVC)) and then dried. Such methods more accurately reflect the applications in real-life clinical practice. This article summarizes the available methods for assessing the virucidal activity of chemical disinfectants for use in medical facilities based on the current European standards, including the activity against coronaviruses.
Highlights
As a result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)pandemic, the interest and demand for virucidal disinfectants have increased
Phase 2/Step 1 tests use quantitative suspension methods, in which the organisms exposed to the chemical disinfectants or antiseptics at various concentrations, times are exposed to the chemical disinfectants or antiseptics at various concentrations, and temperatures and with the addition of interfering substances
human papillomavirus (HPV) is resistant to certain high-level disinfectants (HLD), such as glutaraldehyde and ortho-phthalaldehyde, in both suspension [28] and carrier tests [29]
Summary
Pandemic, the interest and demand for virucidal disinfectants have increased. Some studies have evaluated the virucidal activity of chemical preparations against coronaviruses [1,2,3]. The susceptibility of viruses to chemical disinfectants varies depending on their structure These factors must be considered when assessing the virucidal activity of chemical disinfectants. Nonenveloped viruses with strong hydrophilic properties (e.g., poliovirus, hepatitis A virus (HAV) and parvoviruses) are the most resistant to chemical disinfectants [9,10]. Phase 2/Step 1 tests use quantitative suspension methods, in which the organisms are. Phase 2/Step 1 tests use quantitative suspension methods, in which the organisms exposed to the chemical disinfectants or antiseptics at various concentrations, times are exposed to the chemical disinfectants or antiseptics at various concentrations, and temperatures and with the addition of interfering substances. The current standards for assessing the virucidal activity of chemical disinfectants are.
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