Abstract
Background:Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn’t satisfactory. Methods:We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed. Results:High Amphiregulin, PTEN and low P21 expression levels were associated with low tumor grade (p= 0.038 and 0.025 respectively), better response to anti-EGFR treatment (p <0.001), and favorable outcome {progression-free survival (PFS) and overall survival (OS)} (p <0.05). There was a direct relation between Amphiregulin and PTEN expressions (phi coefficient=+0.840), while there was an inverse relation between P21expression and both Amphiregulin (phi coefficient= -0.840) and PTEN expressions (phi coefficient = -1.000), which was statistically significant (P <0.001). Conclusion: High Amphiregulin and PTEN expression levels and low P21 expression levels were associated with better response to anti-EGFR therapy and improved survival outcome. They might be considered predictive markers of response to anti-EGFR therapy in mCRC.
Highlights
Colorectal carcinoma (CRC) is the fourth commonest diagnosed cancer and the second cause of cancer-related mortality in the United States (Siegel et al, 2019)
We assessed the expression of Amphiregulin, Phosphatase and tensin homologue (PTEN), and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided metastatic colorectal carcinoma (mCRC) using immunohistochemistry (IHC)
Despite the effectiveness of cetuximab regarding the management of patients with mCRC, it showed a considerable number of those patients appear not to benefit from it due to acquired or inherited drug resistance in some patients (Zhang et al, 2018)
Summary
Colorectal carcinoma (CRC) is the fourth commonest diagnosed cancer and the second cause of cancer-related mortality in the United States (Siegel et al, 2019). Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed. Conclusion: High Amphiregulin and PTEN expression levels and low P21 expression levels were associated with better response to anti-EGFR therapy and improved survival outcome. They might be considered predictive markers of response to anti-EGFR therapy in mCRC
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