Abstract
This paper presents an <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in silico</i> and <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vitro</i> study concerning the application of a trapezoidal prism-based surface plasmon resonance chip to detect colorectal cancer by analyzing the mucosa tissue. The sensor is a multilayered structure and works in the wavelength interrogation mode. Performance parameters related to the metallic film characteristics, such as thickness and type of metal were determined. For the analyzed noble metals, the silver film of 40 nm has the highest sensitivity of 6,454.12 nm/RIU, and the 60 nm-thick presents the best values for full width at half maximum and χ parameter (20.20 nm and 286.63 RIU <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">–1</sup> ). The palladium nanolayer deposition enhanced the sensitivity by 10.81% for copper film and peaks at 6,497.04 nm/RIU for the silver film. The palladium nanolayer also provokes deeper dips in the reflectance spectrum. Tissue phantoms were used to study the sensor response to solid surrounding medium to show the feasibility and the correctness of the proposed methodology.
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