Abstract

mRNA vaccine is one of the newest vaccines during the COVID-19 pandemic. However, the hesitancy of vaccination has always been one of the main problems that impact the extent of vaccine coverage. The largest concern that leads to hesitancy is the lack of knowledge on its safety and side effects. Therefore, our work aims to investigate the safety and side effects of the COVID-19 mRNA vaccine, compare that with the conventional vaccine through literature review, and propose potential causes of those side effects. The hypothesis is that the side effects after receiving the mRNA vaccine are similar to conventional vaccines. We chose studies on Pfizer mRNA and conventional influenza vaccines in this work. Systematic reactions such as fever, muscle aches, headache, and fatigue occurred among recipients in both studies. We found that the percentage of mRNA recipients who experienced systematic or adverse reactions could be close to or less than the percentage of people experiencing the same reactions in the conventional vaccine. These results support the previously stated hypothesis, and our work will help reduce public concern about mRNA vaccines by sharing these results. Future work will focus on a detailed study on potential causes of the side effects.

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