Evaluating the Role of Serum 1,5-Anhydroglucitol Concentrations as an Indicator of Hyperglycemic Changes in Diabetic and Non Diabetic Surgical Patients

Ryuji Tamura

doi:10.4172/2155-6148.1000298

Abstract

Purpose: We investigated the relationship between plasma glucose and serum 1,5-anhydroglucitol (1,5-AG) concentrations in surgical patients to determine the role of 1,5-AG concentrations in perioperative glycemic control. Methods: We enrolled 57 patients (19 with and 38 without diabetes) in the study, who underwent hepatectomy under general anesthesia with sevoflurane and remifentanil. Plasma glucose and serum 1,5-AG concentrations were measured and their correlations were evaluated. Results: In all patients, plasma glucose concentrations increased significantly during hepatectomy, but serum 1,5-AG concentrations declined after surgery. Linear regression analysis revealed a weak but significant correlation between the decrease rate of 1,5-AG concentrations and the increase rate of plasma glucose concentrations. Regression analyses revealed this correlation to be more intense in patients without diabetes than in all patients, whereas no correlation was observed in patients with diabetes. These results suggest that serum 1,5- AG concentrations decrease significantly in proportion to increase in plasma glucose concentrations in patients without diabetes, but are less sensitive to such changes in patients with diabetes. Consequently, this indicates that preoperative serum 1,5-AG concentrations in patients with diabetes are too low to be influenced by glycemic fluctuations. In both patient groups, decreased 1,5-AG concentrations did not normalize until 72 h after initiation of surgery. Conclusion: Measurement of 1,5-AG concentrations may be a useful for evaluating glycemic control during anesthesia in patients with normal glycemic metabolism; however, this approach may not be as useful in patients with diabetes as in those without diabetes.

Highlights

Inadequate treatment of hyperglycemia leads to an increase in the prevalence of morbidity and mortality for various medical conditions as well as for surgical procedures [1,2,3]
The assessment of 1,5-AG concentrations might serve as a guide for glycemic control in surgical patients because surgical stressors are known to induce more dynamic changes in plasma glucose concentrations than those observed under normal conditions
The aims of the present study were to investigate the relationship between plasma glucose concentrations and serum 1,5-AG concentrations in surgical patients, and to determine whether serum 1,5-AG concentrations are an accurate indicator of glycemic control in the perioperative period

Summary

Introduction

Inadequate treatment of hyperglycemia leads to an increase in the prevalence of morbidity and mortality for various medical conditions as well as for surgical procedures [1,2,3]. Serum 1,5-AG concentrations fluctuate in response to changes in blood glucose concentrations. This offers more timely information regarding glycemic control than other indicators of glycemia, such as glycated hemoglobin (HbA1c) [5,6,7,8]. As these studies suggest, the assessment of 1,5-AG concentrations might serve as a guide for glycemic control in surgical patients because surgical stressors are known to induce more dynamic changes in plasma glucose concentrations than those observed under normal conditions. The aims of the present study were to investigate the relationship between plasma glucose concentrations and serum 1,5-AG concentrations in surgical patients, and to determine whether serum 1,5-AG concentrations are an accurate indicator of glycemic control in the perioperative period

Objectives

Methods

Results

Conclusion