Abstract
BackgroundDental caries are the most common mouth infectious disease and also chronic disease of childhood. Saliva plays different roles in oral cavity; for example, salivary immunoglobulins play significant role in body and oral immunity. Various studies were conducted on the different effects of IgA on oral cavity, especially dental caries, and reported controversial results. The current study aimed to compare salivary IgA level at different stages of dental caries in adults.Material and MethodsA total of 40 adults, aged 20 to 40 years, referred to the department of oral medicine at Qazvin Faculty of Dentistry, were selected voluntarily based on the number of decayed teeth. Their unstimulated saliva was collected by the spitting method. The cases were assigned to 4 groups each of 10, based on the number of decayed teeth, as follows: Group 1: Caries free, Group 2: With 1 or 2 decayed teeth, Group 3: With 3 or 4 decayed teeth, and Group 4: With 5 or more decayed teeth. None of the cases had systemic diseases or the history of using medicines which affect the quality or quantity of saliva. The salivary IgA level of the cases was measured immunoturbidometrically and analyzed by ANOVA and t test.ResultsSignificant difference was observed between the groups 1 and 4, but there was no significant difference between the other groups.ConclusionsAccording to the results of the current study, the salivary IgA can be considered as an index for the function of immune system, which may be increased by the number of decayed teeth. In fact, the increase of salivary IgA is just the response of immune system to the accumulation of microorganisms and may be the attempt of body to control them. Key words:Saliva, IgA, Dental caries.
Highlights
Dental caries is the most common infectious disease in human, which is under the influence of different factors such as race, inheritance, nutritional conditions, culture, and personal hygiene [1,2]
The current study aimed to evaluate the probable relationship between the level of salivary IgA and the number of decayed teeth
After evaluating the normality of data by KolmogorovSmirnov test (P-value >0.05), the ANOVA was used to evaluate data and differences between the groups, which indicated significant differences between the study groups regarding the level of IgA (P-value = 0.046) (Table 2)
Summary
Dental caries is the most common infectious disease in human, which is under the influence of different factors such as race, inheritance, nutritional conditions, culture, and personal hygiene [1,2]. The effects of IgA on oral cavity, focusing dental decays, were evaluated in different studies, but contradictory results were reported; for example, Koga-ito reported the increase of IgA in adults with lower number of decayed teeth, but did not confirm the same results in children [3]. The current study aimed to evaluate the probable relationship between the level of salivary IgA and the number of decayed teeth. The participants were fasted for 2 hours prior to sample collection and sat in a totally relaxed position for several minutes prior to the sampling. Their unstimulated saliva was collected in the sterile tubes within 5 minutes by spitting method. Data were transferred to SPSS version 21 and analyzed by the statistical tests
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
