Abstract
According to the literature, pigmentary disorders have a significantly negative impact on a person's health-related quality of life. Moreover, among pigmentary disorders, incidence of melasma ranks high. The Melasma Area and Severity Index (MASI) is the scale that is generally used to evaluate a melasma-affected area and its severity. However, the relationship between the MASI and Melasma Quality of Life (MELASQoL) scores, as well as the impact of melasma on patients' quality of life, remain unclear. To explore the influence of melasma on patients' lives, analyze the relationship between the MASI and MELASQoL scores, and identify the factors that may be influencing the quality of life of patients with melasma. Two reviewers independently searched four databases (PubMed, Embase, the Cochrane Library, and Web of Science) for literature on quality of life of patients with melasma. In addition to an epidemiological study, a cross-sectional study, and validation studies, gray literature was also included. StataSE version 16 software was used for the meta-analysis. The score of each item on the MELASQoL scale was determined using a random-effects model. Fourteen studies with a total of 1398 melasma patients were included in the systematic review, four of which were eligible for meta-analysis. The relationship between the MELASQoL and MASI scores was found to be mixed. Five studies concluded that the MASI and MELASQoL scores were statistically correlated, while seven studies found no statistical correlation between the two. It is obvious that melasma causes emotional distress and has a negative impact on patients' social lives. Patients were most bothered by the appearance of their skin condition. However, the MELASQoL score had no definite correlation with patient characteristics such as age, education levels, and history. Melasma has a significant negative impact on patients' quality of life. Thus, evaluating the quality of life of patients with melasma should not be ignored. Additionally, utilization of the MELASQoL scale should be considered in the care plan. Further studies with larger sample sizes are needed to confirm the relationship between melasma and quality of life.
Highlights
Pigmentary disorders refer to changes in skin color due to a decrease or increase in pigment
Fourteen studies with a total of 1398 melasma patients were included in the systematic review, four of which were eligible for meta-analysis
Five studies concluded that the Melasma Area and Severity Index (MASI) and MELASQoL scores were statistically correlated, while seven studies found no statistical correlation between the two
Summary
Pigmentary disorders refer to changes in skin color due to a decrease or increase in pigment. Most pigmentary disorders do not cause significant harm to physical health, several studies have reported that pigmentary disorders may have a significant negative impact on a person’s health-related quality of life [1]. A tan pigmentation spot formed on the face, is caused by a variety of factors It primarily affects women with Fitzpatrick III-VI skin, certain genes, UV exposure, specific hormone levels, or those using drugs or cosmetics with specific ingredients [2,3,4,5,6]. Pigmentary disorders have a significantly negative impact on a person’s health-related quality of life. The relationship between the MASI and Melasma Quality of Life (MELASQoL) scores, as well as the impact of melasma on patients’ quality of life, remain unclear
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