Abstract
Lead is one of the most important environmental, human hazard. Accordingly, the lead (II) absorption capability of the mucilaginous seed of psyllium (Plantago ovate) in mice was investigated. Experimental mice were divided into six groups: healthy control, psyllium groups (1 and 2% psyllium), Lead group (75 mg/kg body weight lead), and psyllium + Lead groups (1 & 2% psyllium and 75 mg/kg body weight lead). The amount of lead in weekly feces samples and liver, kidney, and brain tissue after 5 weeks were measured by the atomic absorption method. At the end of the experimental period, the histopathological lesions of the kidney, liver, brain, and intestine were examined. The results indicated that psyllium increases the fecal excretion of lead and decrease its tissue absorption. Oral administration of the 2% psyllium, significantly reduced the pathological lesions of the kidney, liver, brain, and intestine caused by lead. The use of psyllium seed in lead-exposed populations is recommended.
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