Evaluating the impact of cannabis use on thalamic connectivity in youth at clinical high risk of psychosis.

Lisa Buchy,Alan Anticevic,Jean Addington,Larry J Seidman,Thomas H Mcglashan,Kristina Lyngberg,Scott W Woods,Kristin S Cadenhead,Ming T Tsuang,Tyrone D Cannon,Daniel H Mathalon,Barbara A Cornblatt,Carrie E Bearden,Diana O Perkins,Elaine F Walker

doi:10.1186/s12888-015-0656-x

Abstract

BackgroundDisruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psychosis on thalamic dysconnectivity is poorly understood. We tested whether thalamic dysconnectivity is related to patterns of cannabis use in a CHR sample.Methods162 CHR and 105 control participants were assessed on cannabis use severity, frequency, and age at onset of first use as part of the North American Prodrome Longitudinal Study and completed resting-state fMRI scans. Whole-brain thalamic functional connectivity maps were generated using individual subjects’ anatomically defined thalamic seeds.ResultsThalamic connectivity did not significantly correlate with current cannabis use severity or frequency in either CHR or controls. In CHR cannabis users, a significant correlation emerged between attenuated thalamic connectivity with left sensory/motor cortex and a younger age at onset of cannabis use. CHR who used cannabis before age 15 did not differ on thalamic connectivity as compared to CHR who used after age 15 or CHR who were cannabis naïve. No group differences in thalamic connectivity emerged when comparing CHR separated by moderate/high use frequency, low-frequency or cannabis naïve.ConclusionsAlthough a younger age at onset of cannabis use may be associated with disrupted thalamo-cortical coupling, cannabis use does not appear to be an identifying characteristic for thalamic connectivity in CHR with moderate/high use frequency compared to low-frequency users or CHR who are cannabis naïve.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-015-0656-x) contains supplementary material, which is available to authorized users.

Highlights

Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis
The existing literature suggests that people at genetic risk for schizophrenia and people with schizophrenia are vulnerable to brain volume loss with greater exposure to cannabis, the current results suggest that in people at CHR of psychosis thalamic neural circuitry is not affected by higher severity or usage rates of cannabis
The current study focused on the thalamus, both CHR and chronic patients with schizophrenia have been characterized by alterations across striatal and cortical networks [45,46,47,48,49], and the effects of cannabis use on connectivity in these circuits has not been established

Summary

Introduction

Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. A very recent study [7] in CHR youth observed a pattern of thalamic dysconnectivity similar to that seen in schizophrenia, that was more severe in those who later converted to schizophrenia. Both patterns of thalamic dysconnectivity significantly correlated with attenuated positive symptom severity. This series of reports suggests that aberrant thalamic modulation of information to and from cortical foci occurs prior to the onset of psychosis and may in part underlie the pathophysiology of. The degree to which these functional brain alterations are impacted by well-known risk factors for psychosis is poorly understood

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Discussion

Conclusion