Abstract
The molluscum contagiosum virus (MCV) is a dermatotropic poxvirus. The causative agent of molluscum contagiosum (MC) is nonlethal, common and worldwide. Additionally, little inflammation is associated with MC papules. The present study aims to evaluate the immune status of MC patients by measuring the level of immunoglobulins IgG and IgM by using the radial immune diffusion assay (RIA) and the level of interleukin 18 receptor 1 (IL-18R1) by the Enzyme-linked immunosorbent assay (ELISA).The study is conducted during November 2013 to April, 2014 in outpatient clinic of Baquba Teaching Hospital. There are 75 patients, diagnosed with clinical lesions of MCV on different areas of the body, whose age is ranged between 2-50 years including 40(53.3%) males and 35(46.7%) females. The study includes 15 healthy persons age between 2-50 years. The level of IL 18R1 were significantly elevated in patients (677.15±874.22) compared with control (178.46±31.79 ng/ml). There is also a significant elevation in the mean level of serum IgM, where it is 1946.6±825.6 mg/dl while in control group is 140.1±68.7mg/dl. By contrast in patients with lower levels of IgG than the control, the mean serum IgG level in patient is 221.9±96.7 mg/dl while in the control is 1229.9±299.7 mg/dl. Finally, there is no significant difference between MC patients from rural area and urban area.
Highlights
Molluscum Contagious Virus (MCV)is first described and later named by Bateman in the early nineteenth century [1]
Most adults are more resistant to MCV infection than children because they have developed IgG antibodies against the viral antigen [4]
The study of the immune status of patients infected with the Molluscum contagiosum virus is the first study whether in Diyala governorates or in Iraq, so the present study aims at assessing the immune status of patients infected with molluscum contagiosum through the measurement of the level of immunoglobulin (IgG,IgM) by the radial immune diffusion assay and measuring the level of interleukin 18 by Elisa assay which immune responses are key for the eventual resolution of MC
Summary
Molluscum Contagious Virus (MCV)is first described and later named by Bateman in the early nineteenth century [1]. Molluscum contagiosum virus contains an IL-18 binding protein gene that it apparently acquire from humans This blocks the host’s initial effective Th-one immune response against the virus by reducing local IFN-gamma production [3], IL-18, a recently described member of the IL-1 cytokine super family ,is currently recognized as an important regulator of innate and adaptive immune responses. This little review will describe the basic biology of IL-18 and thereafter address its potential effector and regulatory role in several human disease states including autoimmunity and infection such as MCV infection. The study of the immune status of patients infected with the Molluscum contagiosum virus is the first study whether in Diyala governorates or in Iraq, so the present study aims at assessing the immune status of patients infected with molluscum contagiosum through the measurement of the level of immunoglobulin (IgG,IgM) by the radial immune diffusion assay and measuring the level of interleukin 18 by Elisa assay which immune responses are key for the eventual resolution of MC
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