Abstract
ObjectiveBreast cancer is one of the most common health problems. It has been suggested that several risk factors, either considered as external or internal, play a critical role in the pathogenesis of breast cancer, which among them, HERV-k, has the most fundamental role. In the present study, we aimed to evaluate the role of HERV-k env, gag, rec, np9 expressions in breast cancer progression.Materials and methodsWe collected 40 breast cancer tissues and their normal adjacent ones. After extracting the RNA of breast samples, we evaluated the expression of HERV-k env, gag, rec, np9 by using Quantitative real-time PCR (qRT-PCR).ResultsThe resulting data revealed that while there was a meaningful increase in the expression level of HERV-k env, gag and np9 in breast cancer tissues (P ≤ 0.01, 0.05, 0.05, respectively), we failed to find any significant elevation in the expression level of rec mRNA level.ConclusionThe results of our study suggested that there is a plausible correlation between the mRNA expression level of HERV-K env, gag and np9 and the progression of breast cancer, proposing these markers as promising biomarkers to diagnose breast cancer.
Highlights
The diagnostic approaches in breast cancer, as the second most prevalent cause of cancer death in womankind [1, 2], still remain challenging for clinician, opening the way for the recognition of new biomarkers for early detection of this malignancy
The results of our study suggested that there is a plausible correlation between the mRNA expression level of Human endogenous retrovirus (HERV)-K env, gag and np9 and the progression of breast cancer, proposing these markers as promising biomarkers to diagnose breast cancer
As the relationship between the expression of HERV-K np9, rec, env and gag and breast cancer remains to be an open to Tavakolian et al Infectious Agents and Cancer (2019) 14:42 debate, in this study, we evaluated the expressions of HERV-K np9, rec, env and gag genes in patients suffering from breast cancer
Summary
The diagnostic approaches in breast cancer, as the second most prevalent cause of cancer death in womankind [1, 2], still remain challenging for clinician, opening the way for the recognition of new biomarkers for early detection of this malignancy. The heterogeneous characteristic, complex etiology, diverse genetic mutation and the various distinct clinical manifestations suggested that a wide variety of internal and external risk factors could be involved in the pathogenesis of breast cancer. Apart from external risk factors, such as obesity, smoking, consumption of alcohol and the level of melatonin hormone, internal risk factors, including genetic and epigenetic could initiate signaling pathways in breast cancer through regulation of different genes [3,4,5,6,7,8,9]. Tavakolian et al Infectious Agents and Cancer (2019) 14:42 debate, in this study, we evaluated the expressions of HERV-K np, rec, env and gag genes in patients suffering from breast cancer
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