Evaluating the Efficacy of Tetracycline Local Drug Delivery in Managing Oral Lesions Caused by Pathogens: A Comparative Study

Abstract

Background: Oral lesions caused by pathogens represent a significant clinical challenge, necessitating effective management strategies. Due to its antimicrobial properties, tetracycline local drug delivery has shown promise in combating such lesions. This study aims to evaluate the efficacy of tetracycline local drug delivery compared to conventional treatments in managing oral lesions caused by pathogens. Materials and Methods: A comparative study was conducted involving 100 patients diagnosed with oral lesions attributable to pathogenic infections. Patients were randomly assigned to either the tetracycline local drug delivery group or the conventional treatment group. The tetracycline group received locally administered tetracycline, while the conventional group received standard treatments such as antiseptic mouthwashes or topical corticosteroids. Lesion size, pain scores, and microbial load were assessed at baseline and after four weeks of treatment. Results: In the tetracycline local drug delivery group, the mean reduction in lesion size was 50%, compared to 30% in the conventional treatment group (p < 0.05). Pain scores decreased significantly in both groups, with a greater reduction observed in the tetracycline group (p < 0.01). Microbial load showed a significant decrease in the tetracycline group compared to the conventional group (p < 0.001). Conclusion: Tetracycline local drug delivery demonstrates superior efficacy in managing oral lesions caused by pathogens compared to conventional treatments. It significantly reduces lesion size, pain scores, and microbial load. Incorporating tetracycline local drug delivery into clinical practice could offer a more effective approach to treating such oral lesions.