EVALUATING THE EFFECTIVENESS OF PRIMARY ANALGESIC AND SUBSEQUENT COMBINED MET–THERAPY IN RENAL COLIC THERAPY

Abstract

Renal colic is an acute pathological symptom complex, which, despite all the achievements of medicine, demonstrates constant occurrence rate of about 12% in the human population. This condition is characterized by a pronounced sudden pain attack, which causes significant suffering to the patient. Therefore, the search for effective and safe methods of analgesia and the search for ways to correct urinary obstruction as a cause of pain are of great clinical importance. The aim of the study was to assess the effectiveness of analgesic and combined lithoeradicative therapy to improve the management of patients with acute attack of renal colic. The clinical study included 228 individuals admitted to the hospital with a diagnosis of renal colic. At the first stage, they were divided into three groups to assess the effectiveness of the pharmacological management of primary analgesia. At the second stage, 96 patients were examined, and then divided into 2 subgroups in order to assess the effectiveness of medical expulsive therapy in its mono–variant and in combination with spasmolytics. The results obtained demonstrated that during the primary analgesic therapy of renal colic, non–steroidal anti–inflammatory drugs have advantages over the opioid group that is manifested by a stronger analgesic effect and less severe adverse reactions. Diclofenac showed the best results in pain relief, superior to other drugs by 5–7%. When evaluating the effectiveness of combined medical expulsive therapy, the data obtained indicate an increase in the chances of calculi passage by 11% in the group, which received drotaverine additionally to the therapeutic scheme, and, consequently, a decrease in the number of patients requiring further surgery. This group also demonstrated a pain reduction by 6–7%. Summarizing the data obtained, we can recommend the administration of diclofenac in a dose of 75 mg for primary analgesia of renal colic, and when conducting medical expulsive therapy, combine α–blockers and spasmolytics should be applied. This will lead to improved clinical results in patients with renal colic.