Abstract
In this meta-analysis, we evaluated the effectiveness of isolation precautions in preventing the spread of Multidrug-Resistant Organisms (MDROs) in hospital settings, focusing on contact precautions, use of Personal Protective Equipment (PPE), and cohorting of patients. Through a comprehensive literature search, 48 studies were included, highlighting the significant role these measures play in mitigating MDRO transmission. Findings demonstrate that isolation precautions, particularly contact precautions and PPE usage, significantly reduce MRSA and VRE transmission rates. Cohorting patients also proves effective, especially during outbreaks. This study underscores the importance of implementing stringent, evidence-based isolation precautions across healthcare settings to enhance patient safety and healthcare quality. The results advocate for continuous education, adherence monitoring, and tailored infection control strategies to address the dynamic challenges of MDROs in healthcare environments.
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