Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial

Molebogeng X Rangaka,Robert Horne ,Yohhei Hamada,Alex Ghanouni,Amy L Clarke ,Joanna Calvert ,Heinke Kunst,Helen Booth ,Charlotte Layton,Julian Surey,Chris Griffiths,Henry Bern ,Dominik Zenner,Vanessa Hack,Karen Sanders,Mike Mandelbaum,Trinh Duong,Peter J White ,Angela M Crook ,Ellen Owen-Powell,Marie Francis,Marc Lipman,Ibrahim Abubakar

doi:10.1136/bmjopen-2021-057717

Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial

Molebogeng X Rangaka, Robert Horne + Show 21 more

Open Access

https://doi.org/10.1136/bmjopen-2021-057717

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Journal: BMJ Open	Publication Date: Sep 1, 2022
Citations: 4	License type: open-access

Affiliation: University College London, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, MRC Clinical Trials Unit, Queen Mary University of London, University College London Hospitals NHS Foundation Trust, Whittington Health NHS Trust, Public Health England, Imperial College London, Royal Free London NHS Foundation Trust, Royal London Hospital

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Abstract

IntroductionThe successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based regimens and...

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