Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial

Molebogeng X Rangaka,Dominik Zenner,Vanessa Hack,Charlotte Layton,Joanna Calvert ,Angela M Crook ,Julian Surey,Henry Bern ,Karen Sanders,Helen Booth ,Mike Mandelbaum,Chris Griffiths,Robert Horne ,Marie Francis,Trinh Duong,Alex Ghanouni,Yohhei Hamada,Ellen Owen-Powell,Peter J White ,Heinke Kunst,Amy L Clarke ,Marc Lipman,Ibrahim Abubakar

doi:10.1136/bmjopen-2021-057717

Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial

Molebogeng X Rangaka, Dominik Zenner + Show 21 more

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https://doi.org/10.1136/bmjopen-2021-057717

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Journal: BMJ Open	Publication Date: Sep 1, 2022
Citations: 4	License type: open-access

Affiliation: University College London, Queen Mary University of London, MRC Clinical Trials Unit, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, University College London Hospitals NHS Foundation Trust, Whittington Health NHS Trust, Public Health England, Imperial College London, Royal Free London NHS Foundation Trust, Royal London Hospital

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Abstract

IntroductionThe successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based regimens and...

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