Abstract
BackgroundNo definitive protocol has been introduced for treatment or prevention of chemotherapy induced mucositis. The aim of this study was to assess the additive effect of Persica and chlorhexidine on chemotherapy induced mucositis of children with hematomalignancies. Material and MethodsThis randomized clinical trial was performed on 44 children aged 6 to 12 years who were under a similar maintenance chemotherapy protocol for their hematomalignancies. The clinician instructed oral hygiene cares to the patients and their parents and the severity of the mucositis and oral health status of patients were evaluated according to Oral Assessment Guide index. Then, the patients were randomly assigned to one of two experimental groups and were instructed to rinse either with Persica oral drops or normal saline, twice a day for two weeks. Subsequently, the patients in both groups were educated to rinse with chlorhexidine for 30 seconds and avoid eating for an hour. Second and third oral examinations were performed on the 8th and 15th day using the same questionnaire. ResultsComparing severity of mucositis and oral health status of patients did not show any significant difference between treatment groups in either of examination sessions (p>0.05). However, both treatment groups showed statistically significant oral health improvement, in terms of mucositis, plaque accumulation and gingival condition, in 14 days following mouthrinses administration (p<0.05). ConclusionsBoth mouth-rinse combinations were effective on mucositis, plaque and gingival status of children receiving chemotherapy. However, Persica does not seem to pose additional effect on chlorhexidine in decreasing severity of chemotherapy induced mucositis. Key words:Mucositis, chemotherapy, children, chlorhexidine, Persica.
Highlights
Cancer is the third leading cause of death in Iran
As various chemotherapy protocols is practiced in different care centers and studies, it is not practical to predict the incidence rate of mucositis in each chemotherapy regimen
No guideline has been published on the efficacy of chlorhexidine mouthwash for prevention or treatment of chemotherapy induced oral mucositis in both adults and children population receiving chemotherapy, it seems to be beneficial, as it is effective in management of gingivitis and plaque accumulation, two common oral complication in these patients due to their poor oral hygiene [9]
Summary
Cancer is the third leading cause of death in Iran. Leukemia, lymphoma and CNS tumors have been shown to be the most common childhood malignancies in Iran [1, 2]. No guideline has been published on the efficacy of chlorhexidine mouthwash for prevention or treatment of chemotherapy induced oral mucositis in both adults and children population receiving chemotherapy, it seems to be beneficial, as it is effective in management of gingivitis and plaque accumulation, two common oral complication in these patients due to their poor oral hygiene [9]. Oral assessment guide (OAG) seems to be an appropriate scale for assessing mucositis in both adult and pediatric populations In this regard, each of the 8 items of teeth, gingiva, buccal mucosa, lips, tongue, voice, swallow and saliva, receive score 1 (normal condition), 2 (mild changes without loss of the function or mucosal barrier) or 3 (severe changes with loss of the function or mucosal barrier). The aim of this study was to assess the additive effect of persica on chlorhexidine mouthwash in oral health status of children receiving chemotherapy for their hematomalignancy. Persica does not seem to pose additional effect on chlorhexidine in decreasing severity of chemotherapy induced mucositis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
