Abstract
Background: Touch/ imprint cytology has been utilized for intraoperative evaluations of tumors to complement frozen sections in order to reach diagnosis prior to histopathology diagnosis. The main aim of this study is to find role of touch imprint in determining histopathology diagnosis of ovarian neoplasm.
 Materials and Methods: All together one hundred three cases were evaluated using both touch/imprint and histopathology diagnosis. The histopathology diagnoses consisted of Benign (n=85), borderline (n=4), and malignant (n=12). Touch imprint cytology consists of Negative for malignancy (n=90), Positive for malignancy (n=11) and inadequate (n=2). Inadequate smear was excluded from the study.
 Results: Both touch / imprint cytology were able to diagnose benign and malignant ovarian neoplasm. Out of 103 cases, in cytology showed 89.1% patients were negative and 10.9% patients were positive. Histopathology shows 84.2% of benign ovarian neoplasm, 3.9% borderline neoplasm and 11.9% of malignant. Diagnostic accuracy of touch/ imprint was 99% with sensitivity 100% and specificity was 91.67%. Positive predictive value was 98.89% and negative predictive value was 100%.
 Conclusion: Touch/ imprint cytology examination is simple, rapid and useful test in evaluation of ovarian neoplasms. It plays very important role in preliminary intraoperative diagnosis of benign and malignant ovarian neoplasms.
Highlights
Dudgeon and Patrick from London developed a simple method to obtain rapid diagnosis of freshly cut specimens, in 1927.1 Popularity of touch imprint has increased in cytopathology practice after increase of hematopathology case and frozen section
In an intraoperative consultation, the application of both imprint cytology and histological diagnosis of frozen sections has been recommended for ovarian tumors.[9,10,11]
Out of 101 cases 89% (n=90) cases shows benign and 11% (n=10) cases show malignant in touch imprint cytology
Summary
Dudgeon and Patrick from London developed a simple method to obtain rapid diagnosis of freshly cut specimens, in 1927.1 Popularity of touch imprint has increased in cytopathology practice after increase of hematopathology case and frozen section. Intraoperative cytology (IC) is performed by taking imprint smears from the cancerous tissue and establishing an early diagnosis at the operation site.[2] Ovarian cancer is eight most common cancer among women, and it includes about 4% of all women's cancer.[3] Lifetime risk of ovarian cancer in women is one in 71, and the chance of dying from the disease is 1 in 95.4 Malignant epithelial tumors of ovary are usually aggressive and they. Patients with benign epithelial tumors may present with features mimicking malignancy like large abdominal-pelvic mass in case of mucinous cystadenoma, if correctly diagnosed on IC, requires cystectomy only.[5] Intraoperative cytology diagnosis helps to manage patient during the operative procedure and process further in the benefit of the patient management. In an intraoperative consultation, the application of both imprint cytology and histological diagnosis of frozen sections has been recommended for ovarian tumors.[9,10,11] We underwent this study to evaluate the accuracy of imprint cytology/ touch preparation in the diagnosis of ovarian neoplasms and correlate it with histopathological diagnosis
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