Abstract

Highlights
Beta thalassemia syndrome is a group of hereditary blood disorders that are mainly characterized by reduction or absence of β-globin chain synthesis, resulting in a reduction of hemoglobin in red blood cells (RBCs), decreased production of RBCs and anemia [1,2]
This depends on the transfusion needs of each individual in order to maintain a hemoglobin level between 9 and 10 g/dLto promote normal growth, normal physical activity, and to inhibit ineffective erythropoiesis[26]
quality of life (QoL) in patients with β-TM is affected by disease complication as they obviously associated with dramatic psychological effects, hopelessness, emotional burden and social integration problems [15,27]
Summary
Beta thalassemia syndrome is a group of hereditary blood disorders that are mainly characterized by reduction or absence of β-globin chain synthesis, resulting in a reduction of hemoglobin in red blood cells (RBCs), decreased production of RBCs and anemia [1,2]. In Iraq, there is a high prevalence of β-TM. Thalassemia is an autosomal recessive genetic condition, caused by point mutation within or near β-gene. Such mutations result in either absence of the β gene (β0-thalassemia) or reduction in synthesis of the β gene (β+-thalassemia)(6). Without iron chelation therapy (ICT) the regular blood transfusion would increase the iron stores to several times the normal levels, iron overload results in severe complications including cardiac disease, osteopathy and endocrine complications[9,10]
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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