Evaluating deviations in prostatectomy patients treated with IMRT

Abstract

AimTo evaluate the deviations in prostatectomy patients treated with IMRT in order to calculate appropriate margins to create the PTV. BackgroundDefining inappropriate margins can lead to underdosing in target volumes and also overdosing in healthy tissues, increasing morbidity. Material and methods223 CBCT images used for alignment with the CT planning scan based on bony anatomy were analyzed in 12 patients treated with IMRT following prostatectomy. Shifts of CBCT images were recorded in three directions to calculate the required margin to create PTV. Results and discussionThe mean and standard deviation (SD) values in millimetres were −0.05±1.35 in the LR direction, −0.03±0.65 in the SI direction and −0.02±2.05 the AP direction. The systematic error measured in the LR, SI and AP direction were 1.35mm, 0.65mm, and 2.05mm with a random error of 2.07mm; 1.45mm and 3.16mm, resulting in a PTV margin of 4.82mm; 2.64mm, and 7.33mm, respectively. ConclusionWith IGRT we suggest a margin of 5mm, 3mm and 8mm in the LR, SI and AP direction, respectively, to PTV1 and PTV2. Therefore, this study supports an anisotropic margin expansion to the PTV being the largest expansion in the AP direction and lower in SI.