Evaluating computational models of language disturbance in schizophrenia

Uli Grasemann,Douglas Lane,Donald Quinlan,Ralph E Hoffman,Ralitza Gueorguieva,Risto Miikkulainen

doi:10.1186/1471-2202-11-s1-p99

Abstract

Uli Grasemann and Risto Miikkulainen are with the Department of Computer Science, University of Texas at Austin, USA -- Ralph E. Hoffman, Ralitza Gueorguieva and Donald Quinlan are with the Department of Psychiatry, Yale University School of Medicine, USA -- Douglas Lane is with the Geriatrics and Extended Care Service, VA Puget Sound Healthcare System, USA

Highlights

Abnormal brain processes that underlie schizophrenia are incompletely understood, and no current laboratory or imaging technique can reliably identify individuals with schizophrenia
Establishing the brain processes underlying the symptoms of schizophrenia would greatly advance our understanding of this disorder
Kapur proposes that in schizophrenia, an overabundance of midbrain DA activity leads to a pathological enhancement of salience, which in turn causes psychotic symptoms

Summary

Introduction

Abnormal brain processes that underlie schizophrenia are incompletely understood, and no current laboratory or imaging technique can reliably identify individuals with schizophrenia. Establishing the brain processes underlying the symptoms of schizophrenia would greatly advance our understanding of this disorder. After almost a century of clinical research, they remain incompletely understood.

Results

Conclusion