Abstract
Dehydration treatment is commonly applied to treat intracranial hypertension. We previously utilized electrical impedance tomography (EIT) for noninvasively monitoring the efficacy of dehydration treatments and found it could provide references for the rational use of dehydrating drugs. In addition to brain tissues, scalp undergoes dehydration and can cause impedance changes, which may hamper the monitoring results of intracranial dehydration through EIT. To address this problem, we first conducted simulation and animal experiments to evaluate the impact of scalp dehydration on the monitoring results of EIT during dehydration treatments. With the priori of the spatial distribution of brain structures and the statistical results of the contribution of scalp dehydration to the intracranial reconstructed values of the EIT images obtained from animal experiments, we then proposed a weighting algorithm to reduce the impact of scalp dehydration. The experimental results showed that scalp impedance changes would to some extent reduce the accuracy of EIT in imaging intracranial resistive perturbation and account for 16.7% in overall changes of EIT signal. With the modified algorithm, 69.6% of reconstructed values of scalp dehydration in EIT images were eliminated. And the image contrast (IC) of reconstructed EIT images was improved by 21.0%. Therefore, we conclude that scalp dehydration influences the accuracy of EIT in reflecting intracranial dehydration and our proposed method can reduce the impacts of scalp dehydration.
Highlights
Electrical impedance tomography is a non-invasive, low cost and real time imaging method, which has been widely studied in biomedical fields including in the imaging of ventilation, brain function, brain injury, and gastric motility [1]–[4]
OF EVALUATION EXPERIMENTS In this part, we show the results of the simulation and animal experiments for evaluating the impact of scalp dehydration on the monitoring results of brain electrical impedance tomography (EIT) in mannitol dehydration
The averages of δρall | intra and δρscalp| intra are 0.092 and 0.61 /m; from this, we find that the contribution of scalp dehydration to the reconstructed impedance changes in the intracranial area in EIT images is approximately 15.2%
Summary
Electrical impedance tomography is a non-invasive, low cost and real time imaging method, which has been widely studied in biomedical fields including in the imaging of ventilation, brain function, brain injury, and gastric motility [1]–[4]. Intracranial hypertension is a severe pathology in brain which can cause reduced cerebral blood supply, neurological damage and even death [5]. The associate editor coordinating the review of this manuscript and approving it for publication was Sudipta Roy. commonly applied to reduce elevated intracranial pressure (ICP) [6]. Patients may have different sensitivities to dehydration drugs. The improper use of drugs can cause problems in controlling the ICP and lead to side effects. The repeated use of mannitol with excessive dosage may harm renal function, cause ‘‘rebound’’ phenomenon, and aggravate cerebral edema [7]. A device that can monitor the efficacy of dehydration treatments is required to provide references for personalized medication [8]
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