Abstract
To see what function cell swelling played in severe hemorrhagic shock and resuscitation injury. This study was done in the department of General surgery after ethical permission from December 2019 to September 2021. Adult rats were administered a low volume resuscitation (LVR) (10–20 percent blood volume) with saline or several cell impermeants (sorbitol, raffinose, trehalose, gluconate, and Polyethylene glycol-20k) after being haemorrhaged to a pressure of 30–35 mm Hg and kept there until plasma lactate reached 10 mM. (PEG-20k). When lactate returned to 10 mM after LVR, complete resuscitation using crystalloid and red cells was initiated. The rats were euthanized one hour after complete resuscitation. The colourful microsphere technique was used to measure capillary blood flow. Impermeants significantly enhanced LVR outcomes in shocked rats by preventing ischemia-induced cell swelling in liver tissue. In comparison to saline, small cell impermeants and PEG-20k in LVR solutions increased tolerance to the low flow condition by 2 and 5 fold, normalised arterial pressure during LVR, and reduced plasma lactate after full resuscitation.
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